Pharmacokinetics
Semax is a synthetic peptide, acting as an analog of adrenocorticotropic hormone. The adrenocorticotropic hormone regulates many processes related to stress and bodily rhythm.[3] When administered, semax has been found to increase levels of brain-derived neurotrophic factor, or BDNF. Through this increase in BDNF, it is theorized that semax optimizes cognitive and hormonal functioning.[2]
Scientific Studies
Multiple studies have been carried out to determine the effects and benefits of semax. One study on animals saw a 40% increase in BDNF levels. In this experiment, semax was used regularly and intranasally. This led researchers to the conclusion that semax modulates levels of BDNF in the hippocampus.[2] Another study looked into the effects of semax on the serotonin and dopamine systems within the brain. Subjects were injected with semax, and notable increases in activity were observed.[4]
Sources:
[1] http://apps.who.int/medicinedocs/en/m/abstract/Js19766ru/
[2] https://www.ncbi.nlm.nih.gov/pubmed/16996037
[3] https://www.annualreviews.org/doi/10.1146/annurev-physiol-021909-135821
[4] https://www.ncbi.nlm.nih.gov/pubmed/16362768
[5] https://www.ncbi.nlm.nih.gov/pubmed/22293371
[6] https://selfhacked.com/blog/all-about-semax/
[7] https://www.verywellhealth.com/injection-side-effects-call-doctor-2616542
